Evidence of Defective Growth Hormone Response and Adaptive Hormonal Changes in Fibromyalgia*

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Preliminary Evidence of Increased Pain and Elevated Cytokines in Fibromyalgia Patients with Defective Growth Hormone Response to Exercise.

Mounting evidence suggests fibromyalgia (FM) symptoms are influenced by dysfunction of the hypothalamic-pituitary-hormonal axes (HPHA) and the immune response system. The predominant FM symptoms of widespread pain, fatigue, sleep disturbance, depression, stiffness and exercise intolerance are related to abnormal levels of growth hormone (GH) and are reminiscent of "sickness behavior"; a syndrom...

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High prevalence of growth hormone deficiency in severe fibromyalgia syndromes.

CONTEXT Fibromyalgia (FM) is characterized by widespread pain and fatigue and is considered a syndrome with different pathogenic mechanisms. Controversial data on GH axis disturbances have been published. Some preliminary trials have shown promising effects of GH therapy on tender points and quality of life in FM. AIM The aim was to study the patterns of GH secretion/sensitivity in a cohort o...

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ژورنال

عنوان ژورنال: Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin

سال: 2014

ISSN: 0940-6689,1439-085X

DOI: 10.1055/s-0034-1374614